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Table 4 Comparison of chemosensitizing effects of flavonoids and verapamil against Pgp

From: ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal

Chemosensitizer

IC50 a(μM)

CIc

(VCRb-)

(VCR+)

5,7,3',4',5' – pentamethoxyflavone

> 400

0.4

>1000

7,3',4' – trimethoxyflavone

> 400

1.2

>333.3

3',4' – dimethoxyflavone

386

1.2

321.7

3,6,3',4' – tetramethoxyflavone

> 400

1.9

>210.5

Verapamil

61

0.4

152.5

5,6,7,3',4' – pentamethoxyflavone

> 400

3.2

>125

  1. Cytotoxic and chemosensitizing effects of chemosensitizers in the presence or absence of vincristine in Pgp-overexpressing AML-2/D100 cells.
  2. a, Drug concentrations with inhibit 50% growth of the cells.
  3. b, Vincristine (100 ng/ml)
  4. c, Chemosensitizing index = IC50 (VCR-)/IC50(VCR+)
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Cancer Cell International

ISSN: 1475-2867

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