TEAD4 overexpression promotes epithelial-mesenchymal transition and associates with aggressiveness and adverse prognosis in head neck squamous cell carcinoma

Table 1 The associations between TEAD4 expression and multiple clinicopathological parameters in HNSCC samples

Clinicopathological parameters	Cases	TEAD4		P-values
Clinicopathological parameters	Cases	Low*	High	P-values
Gender	105	55	50
Male	63	33	30	> 0.9999
Female	42	22	20
Age
≤ 60	43	22	21	0.8453
> 60	62	33	29
Smoking
No	74	37	37	0.5232
Yes	31	18	13
Alcohol use
No	83	42	41	0.6319
Yes	22	13	9
Tumor size
T1–T2	74	42	32	0.2011
T3–T4	31	13	18
Pathological grade
I	58	37	21	0.0340
II	34	13	21
III	13	5	8
Cervical node metastasis
N(0)	71	43	28	0.0214
N(+)	34	12	22
Clinical stage
I	19	11	8	0.0397
II	30	21	9
III	25	8	17
IV	31	15	16

* Both of patients with low and negative TEAD4 staining are stratified into low TEAD4 category for simplicity. The number in italic indicate statistical significance with P-values less than 0.05

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