Fig. 2

Phosphorylation, acetylation, methylation, glycosylation, ubiquitination, and sumoylation occur in different regions of the p53 protein and play a crucial role in regulating p53 stability and localization in response to genotoxic stress. p53 ubiquitination mostly occurs at its C terminus, where acetylation also occurs during cell stress and by competing with ubiquitination it prevents p53 downregulation, thus enhancing p53 stability