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Fig. 2 | Cancer Cell International

Fig. 2

From: Methylmalonic acid promotes colorectal cancer progression via activation of Wnt/β-catenin pathway mediated epithelial–mesenchymal transition

Fig. 2

MMA promotes cell migration, invasion and regulates EMT in CRC cells. A–F Transwell assays indicated that MMA promoted the migration and invasion of both HCT116 (A–C) and SW480 (D–F) cells most remarkably. (G–J) Western blot analysis of alterations in protein levels of EMT -related markers showed that epithelial markers were downregulated and mesenchymal markers were upregulated in both HCT116 (G, I) and SW480 (H, J) cells treated with MMA. (**P < 0.01, ***P < 0.001, ****P < 0.0001)

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Cancer Cell International

ISSN: 1475-2867

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