Fig. 5

Metabolomics analysis of OV-CRNDE-M0, M0, and M2 groups. The metabolites of M0 cells, M2 cells and OV-CRNDE-M0 cells were detected by LC-MS/MS. A. Coefficient of Variation (CV) distribution of samples in each group, abscissa represented the CV value, and the ordinate represents the proportion of the number of metabolites less than the corresponding CV value. B. Principal component analysis (PCA) plots of 3 groups, the PC1 and PC2 indicated the first and second principal components, respectively. A single scatter plot represents a sample, and samples from the same group were used in the same color. The distance represents the degree of difference in metabolites. C. Heatmap analysis of 61 metabolites expression from the OV-CRNDE-M0, M0, and M2 groups, with the sample name as abscissa, and metabolite as ordinate. Its color represents the level of each metabolite (red color indicates a high level of expression, green color indicates a low level of expression)