Fig. 8
From: Machine learning unveils key Redox signatures for enhanced breast Cancer therapy
Differential expression and immunohistochemical analysis of immune markers in tumor microenvironments between AIARS subgroups. (A) Heatmap comparing the quantification of immune cell infiltration in tumor samples with low and high AIARS, calculated using various computational algorithms. Each row represents a different immune cell type, with color intensity reflecting the level of infiltration. (B) Box plots indicating the distribution of gene expression levels for ICIs in low vs. high conditions. ns, not significant; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. (C) Representative immunohistochemistry images comparing the staining intensity of various immune markers between high and low expression conditions. (D) Box plots displaying the average optical density (AOD) of staining for immune markers, comparing high and low expression conditions, with statistical significance indicated by stars (* for p < 0.05, ** for p < 0.01, and ns for not significant)