Table 1 S1P inhibitors used in PDAC
S1PRs inhibitors used in pancreatic cancer study | ||||
|---|---|---|---|---|
Compound name | Mechanism | Experiment model | Receptors | Ref. |
FTY720 | Induction of apoptosis through S1PR1 and S1PR1/STAT3 inhibition and AKT/BCL2/NF-kB inhibition | In vitro: MIA PaCa-2, BxPC-3, Panc-1, AsPC-1, Panc02-luc | S1PR1/2 | [87] |
JTE-013 | Downregulation of cancer proliferation through inhibition of S1PR2/PI3K/AKT/ERK signaling pathway | In vitro: MIA PaCa-2, BxPC-3, AsPC-1, Panc02-luc | S1PR2 | |
In vivo: NOD.CB17-Prkdcscid/J mice and C57Bl/6 mice | ||||