Fig. 1
From: STAT3: Key targets of growth-promoting receptor positive breast cancer
Schematic diagram of STAT3 protein structure. Schematics of STAT3 protein structure and function. A The STAT3 protein structure includes an N-segment domain, helix-helix domain, DNA binding domain, linker, Src homology 2 domain, and C-segment domain. The DNA-binding domain of the STAT3 protein is primarily responsible for DNA transcription, while the Src homology domain is primarily responsible for promoting STAT3 protein dimerization. These domains are regulated by the phosphorylation level of Y705 and S727 sites. B The three-dimensional structure diagram of STAT3 protein promotes it's role in DNA binding, dimerization, and reverse transcription