Fig. 4
From: STAT3: Key targets of growth-promoting receptor positive breast cancer
Regulation of STAT3 on basic hallmarks of tumors. Schematic of the regulatory effect of STAT3 on cancer markers. Cancer has 14 basic characteristics, and STAT3 has an essential influence on 13 of these (maintaining proliferation signal, evolving growth inhibitory factor, deregulating cell metabolism, avoiding immune damage, resisting cell death, achieving immortal reproduction, genome instability and mutation, tumor-promoting inflammation, inducing or approaching blood vessels, activating invasion and metastasis, unlocking phenotypic plasticity, non-mutant epigenetic reprogramming, and aging cells)