Table 1 Biological role of STAT3 in HER2 positive breast cancer and luminal breast cancer

HER2

Inhibit high proliferative activity

Patient derived cell lines

4-(tertbutyl)-N-carbamoylbenzamide

Sustaining proliferative signaling

HER2, Ras, STAT3, Ki67

[83]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance

YMB-1, MDA-MB-453

5,15‐DPP

Sustaining proliferative signaling

PI3K/Akt/mTOR pathway, STAT3 pathway

[84]

HER2, Luminal

Inhibit high proliferative activity, Induce apoptosis

SK-BR-3, T47D

Lapatinib,

Canertinib, Afatinib

Sustaining proliferative signaling, Resisting cell death

ERK/MAPK, STAT3, CREB, p70 S6 kinase, IkBa, p38, JNK, STAT5

[85]

HER2

Inhibit high proliferative activity, Induced invasion and metastasis

NMuMG

Ruxolitinib

Sustaining proliferative signaling, Activating invasion & metabolism

HER2, HOXB7, JAK/STAT pathway

[86]

HER2, Luminal

Inhibit high proliferative activity

BT-474, SK-BR-3

Penitrem A

Sustaining proliferative signaling,

BK Channels, p27, EGFR, HER2

Akt, STAT3

[87]

HER2

Inhibit high proliferative activity, Induce apoptosis

LAM patient-derived 621–101 and

621–103 cells

Pyrotinib

Sustaining proliferative signaling, Resisting cell death

EGFR/STAT3/CD24 loop, TSC2

[88]

HER2

Inhibit high proliferative activity

MDA-MB-468

/

Sustaining proliferative signaling

STAT3, GLI1/tGLI1, R-Ras2,

Cep70, UPF3A

[89]

HER2

Inhibit high proliferative activity, Promote tumor cell invasion and metastasis, Promote tumor-related angiogenesis, Promote tumor-related inflammation

SK-BR-3

/

Sustaining proliferative signaling, Inducing or accessing vascular, Tumor promoting inflammation, Activating invasion & metabolism

IL-30, STAT3, STAT1, KISS1, CD11b, Gr1

[90]

HER2, Luminal

Inhibit high proliferative activity, Induce apoptosis

JIMT-1, T47D, MCF-7

Sodium propionate

Sustaining proliferative signaling, Resisting cell death

JAK2/STAT3 Pathway, ROS, p38 MAPK

[91]

HER2

Inhibit high proliferative activity, Induce apoptosis

SK-BR-3

Acetylshikonin

Sustaining proliferative signaling, Resisting cell death

Δ16HER2, DHFR, HER2, Src, STAT3, Caspase-3

[92]

HER2

Inhibit high proliferative activity, Induce apoptosis, Enhance immune evasion

NT2.5

Entinostat

Sustaining proliferative signaling, Resisting cell death, Avoiding immune destruction

STAT3 Pathway, NF-κB Pathway, IL-6, MIP2, TNF-α, GMCSF

[93]

HER2, Luminal

Inhibit high proliferative activity, Induce apoptosis

BT-474

Quercetin

Sustaining proliferative signaling, Resisting cell death

STAT3, MMP9, PRAP, Caspase-3, JAK1, BAX, Bcl-2

[94]

HER2, Luminal

Inhibit high proliferative activity, Induce apoptosis, Promote tumor cell invasion and metastasis

MCF-7

FA modified NPs

Sustaining proliferative signaling, Activating invasion & metabolism, Inducing or accessing vascular

HER2, FR, CA15.3, VEGF, STAT3, TNF-α, IL-6, IL-1β, IL-2

[95]

HER2

Inhibit high proliferative activity, Promote tumor-related inflammation

SUM149, SUM190

Tocilizumab

Sustaining proliferative signaling, Tumor promoting inflammation

IL-6, IL-6R, STAT3, HER2

[96]

HER2

Inhibit high proliferative activity, Promote tumor-related inflammation, Enhance immune evasion

SK-BR-3

Tamoxifen, Stattic

Sustaining proliferative signaling, Tumor promoting inflammation, Avoiding immune destruction

CD206, CD45, JAK, STAT3, CCL5, TNF-α, PD-L1

[97]

HER2, Luminal

Inhibit high proliferative activity

SK-BR-3, MCF-7

Melatonin

Sustaining proliferative signaling, Activating invasion & metabolism,

HER2/MAPK/ERK pathway, Rsk2,

Creb, STAT3,

cSrc, Fak, Pax, Fascin, actin polymerization

[98]

HER2

Inhibit high proliferative activity, Induce apoptosis,

SK-BR-3, BT-474

Ibrutinib

Sustaining proliferative signaling, Resisting cell death

Caspase-3, Caspase-8, PRAP1, p21, STAT3

[99]

HER2

Inhibit high proliferative activity, Induce apoptosis, Inducing tumor-related angiogenesis

/

/

Sustaining proliferative signaling, Resisting cell death, Inducing or accessing vascular

Hippo pathways, PIK3CA^H1047R, eIF4G, STAT3, MAPK, Akt, YAP, BCL-2

[100]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance

SK-BR-3, JIMT-1, HCC1954, AU565

Lapatinib, EDI3 siRNA

Sustaining proliferative signaling,

PI3K/Akt/mTOR pathway, GSK3β, EDI3, HER2, HIF1α, CREB, STAT3

[101]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance, Enhance immune evasion, Induce apoptosis, Avoid cell aging

SK-BR-3, MDA-MB-468,

HCC1419

CD4 + Th1 cell, TNF-α, IFN-γ

Sustaining proliferative signaling, Resisting cell death, Tumor promoting inflammation, Senescent cells

p15INK4a, p15INK4b, EGFR, HER2, HER3, IFN-γRα, TNF-R1, Caspase-3, STAT1, STAT3, JAK1, JAK2, p38 MAPK

[102]

HER2, Luminal

Inhibit high proliferative activity, Induce apoptosis, Promote epigenetic modification

AU565, MCF-7

Trastuzumab, Neratinib, Stattic, Niclosamide

Sustaining proliferative signaling, Resisting cell death, Non-mutational epigenetic reprogramming

TRIM21, HER2, HER3, STAT3, ERK, Akt, p-53, FOXO3a

[103]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance

MDA-MB-453, BT-474, MCF-7/HER2

catecholamine

Sustaining proliferative signaling,

PI3K/Akt/mTOR pathway, β2-AR, miR-21, MUC-1, HER2, STAT3, miR-199a/b-3p

[104]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance, Induce apoptosis, Promote epigenetic modification

SK-BR-3, BT-474

siNCAPG

Sustaining proliferative signaling, Resisting cell death, Non-mutational epigenetic reprogramming

NCAPG, Src, STAT3, Cyclin D1, BCL-2

[105]

HER2

Inhibit high proliferative activity, Promote epigenetic modification

T47D, SUM190

/

Sustaining proliferative signaling, Non-mutational epigenetic reprogramming

Nectin-4, ErbB2, ErbB2, p95-ErbB2, ErbB2ΔEx16, JAK/STAT3 pathway, PI3K/Akt pathway

[106]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance

SK-BR-3

siHES-1, siHIF1α

Sustaining proliferative signaling,

HIF1α, HES-1, STAT3, HER2, Akt, PTEN, p27, Cyclin D, JAK2

[107]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance

SK-BR-3

siIL-6, siSTAT3,

Sustaining proliferative signaling, Unlocking phenotypic plasticity

IL-6, STAT3

[108]

HER2

Inhibit high proliferative activity, Promote tumor-related inflammation

Cell from PDXs

/

Sustaining proliferative signaling, Tumor promoting inflammation,

IL-6, STAT3

[109]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance, Promote tumor-related angiogenesis, Promote tumor-related inflammation

SK-BR-3, BT-474, HCC1954

Ponatinib, Sunitinib

Sustaining proliferative signaling, Tumor promoting inflammation, Inducing or accessing vascular

PDGFRA, PDGBRB, STAT3, ERK, IL-6

[110]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance, Promote tumor cell invasion and metastasis, Maintain the dry level of tumor stem cells

BT-474, MDA-MB-468

Ruxolitinib, Pacritinib,

Vismodegib,Sonidegib

Sustaining proliferative signaling, Activating invasion & metabolism, unlocking phenotypic plasticity

JAK2/STAT3 pathway, SMO/GLI1/tGLI1 pathway, VEGF, CD44, CD24, CD31, BCL-2, Nanog, Ki-67

[111]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance, Induce apoptosis

SK-BR-3

Mycophenolic acid

Sustaining proliferative signaling, Resisting cell death,

Akt/FOXO1 pathway, JAK2/STAT3 pathway, PPAR, p-27, CyclinD1, Caspase-3, HER2, ERK

[112]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance

MDA-MB-468, AU565

Ruxolitinib, Everolimus, Erlotinib

Sustaining proliferative signaling

BCL-2, BIRC8, Akt1, MAPK7, RPS6KA5, EGFR, HER2, JAK3, STAT3

[113]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance

SK-BR-3, BT-474

Ganetespib

Sustaining proliferative signaling

HER2, PI3K/Akt pathway, Ras/MEK/ERK pathway, STAT3, HER3, RGFR, Bcl-xl, Bcl-2, c-Myc, CyclinD1, CDK4

[114]

Luminal

Inhibit high proliferative activity, Regulate the level of cell drug resistance

MCF-7

/

Sustaining proliferative signaling

FGFR/STAT3 pathway, Akt, HER2, gp130, ERK

[115]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance

BT-474,

/

Sustaining proliferative signaling

Caspae-3, STAT3, STAT3, STAT5, HER2, LIFR, HER3, EGFR, IL-6R, GM-CSFR, c-Myc

[116]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance, Promote tumor cell invasion and metastasis, Promote epigenetic reprogramming

HCC1954, SK-BR-3, JIMT-1, BT-474

SNX631

Sustaining proliferative signaling, Activating invasion & metabolism, Non-mutational epigenetic reprogramming

STAT1, STAT3, Akt, miR-21-3p, miR-21-5p, miR-221, BTG2, Ki-67, ARG1, Alpha-SMA

[117]

HER2, Luminal

Inhibit high proliferative activity, Regulate the level of cell drug resistance

MDA-MB-453, HCC1954, MCF-7, T47D

/

Sustaining proliferative signaling

HER2, EGFR, Akt, Ki-67, Caspase-3, JAK2/STAT3 pathway

[118]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance, Promote tumor-related inflammation,

Cell fro PDXs

/

Sustaining proliferative signaling, Tumor promoting inflammation

Src/STAT3/ERK1/2 pathway, RGFR, IL-8,

[119]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance, Promote tumor-related inflammation

HME2-BM

Ruxolitinib, shSTAT3

Sustaining proliferative signaling, Tumor promoting inflammation

STAT3, Akt, AkBa, IL-6, TG2

[120]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance

EFM-192A, BT-474

/

Sustaining proliferative signaling

Fibronectin, Snail, Occludin, E-Cadherin, HER2, ERK, Akt, STAT3

[121]

HER2

Regulate the level of cell drug resistance, Induce apoptosis

SK-BR-3, BT-474, MDA-MB-453

Lapatinib, S3I-201

Resisting cell death

STAT3/Survivin pathway, PRAP, HER2

[122]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance, Induce apoptosis

BT-474

STAT3-decoy ODNs

Sustaining proliferative signaling, Resisting cell death

STAT3, Bcl-2, Mcl-1, Survivin, MUC4, Akt, Caspase-3, Cyto C

[123]

Luminal

Inhibit high proliferative activity, Regulate the level of cell drug resistance, Controlled by genomic instability

MCF-7, BT-474, T47D

siAKTIP, siSGK3, siSTAT3, shAKTIP, siESR1, siCAND1, siFASN, siSUP7

Sustaining proliferative signaling, Genome stability & mutation

AKTIP, ERα, S6, Akt, HOOK1, p70S6K, ERK2, SGK3, SERPINA3, STRADB, TFF1, GREB1, CCND1, NDUFB11, RPRD1B, RAB5B, PERP

[124]

Luminal

Inhibit high proliferative activity, Promote tumor-related inflammation, Maintain the dry level of tumor stem cells, Promote epigenetic reprogramming

MCF-7, SUM159, HCC70

shXIST

Sustaining proliferative signaling, Tumor promoting inflammation, Unlocking phenotypic plasticity, Non-mutational epigenetic reprogramming

XIST, ALDH, CD44, CD24, c-Myc, KLF4, SOX9, STAT3, IL-6, IL-8, miRNA let-7a, SOX2, NF-κB, IL-6R, ALDH1A1

[125]

Luminal

Inhibit high proliferative activity, Regulate the level of cell drug resistance, Induce apoptosis

BT-474, MCF-7

siSTAT3, MID2-MT-OE

Sustaining proliferative signaling, Resisting cell death

STAT3, MID2, MROC4

[126]

Luminal

Inhibit high proliferative activity, Controlled by genomic instability, Enhance immune evasion, Promote tumor cell invasion and metastasis

MCF-7

siSTAT3

Sustaining proliferative signaling,

Activating invasion & metabolism,

Genome stability & mutation,

Avoiding immune destruction

STAT3, PD-L1, STAT1, α-mannosidase II

[127]

Luminal

Inhibit high proliferative activity

MCF-7

/

Sustaining proliferative signaling

PTPN2, Akt, Met, ERK, STAT3, EGFR

[128]

Luminal

Inhibit high proliferative activity,

Promote tumor cell invasion and metastasis

MCF-7, T47D, BT-474

shTBC1D9

Sustaining proliferative signaling,

Activating invasion & metabolism

TBC1D9, ARL8A, ARL8B, PLK1, HIF1α, STAT3, SPP1

[129]

Luminal

Inhibit high proliferative activity,

Promote tumor cell invasion and metastasis, Promote tumor-related angiogenesis, Promote tumor-related inflammation

MCF-7,

shIL-8, siSTAT3

Sustaining proliferative signaling,

Activating invasion & metabolism, Tumor promoting inflammation, Inducing or accessing vascular

Leptin, IL-1β, IL-8, NF-κB p65, STAT3, Akt, Lin28B, EpCAM, N-Cadherin, Twist1, Snail, Vimentin, Ki-67, E-Cadherin, p16, JAK, ZEB1, CD44, CD24, p53, PCNA, CDKN2A, LEP, CXCL8, IL-6, RELA, miRNA Let-7b, HIF1α, VEGFA, mTOR, CD34

[130]

Luminal

Inhibit high proliferative activity,

Promote tumor cell invasion and metastasis

MCF-7

Diallyl Trisulfide

Sustaining proliferative signaling,

Activating invasion & metabolism

STAT3, Bcl-2, Bcl-xl, Cyclin D1, VEGF, MMP2, MMP9

[131]

Luminal

Inhibit high proliferative activity,

Promote tumor cell invasion and metastasis, Maintain the dry level of tumor stem cells, Promote epigenetic reprogramming

MCF-7

siSTAT3

Sustaining proliferative signaling,

Activating invasion & metabolism, Tumor promoting inflammation, Unlocking phenotypic plasticity,

CD44, CD24, ALDH, STAT3, p16, IL-6, EpCAM, α-SMA, E-Cadherin, N-Cadherin, Vimentin, Akt, CD10, SOX2

[132]

Luminal

Inhibit high proliferative activity, Induce apoptosis

MCF-7

Curcumin

Sustaining proliferative signaling, Resisting cell death

NF-κB, IκBα, p53, Bid, STAT3, Caspase-3. Caspase-8, Bax, c-Ha-Ras, Rho-A, Bcl-xl, CCND1

[133]

Luminal

Inhibit high proliferative activity, Controlled by genomic instability

SSM1, SSM2, SSM3

/

Sustaining proliferative signaling, Genome stability & mutation

ERα, STAT1, STAT3, STAT5, PRLR, Rb, JAK2, KRAS

[134]

Luminal

Inhibit high proliferative activity, Induce apoptosis, Maintain the dry level of tumor stem cells

/

/

Sustaining proliferative signaling, Resisting cell death, Unlocking phenotypic plasticity,

EGFR/STAT3 pathway, TGFB/TGF-β/SMAD pathway, ITGB1, CD29, ITGB1, CD61

[135]

Luminal

Inhibit high proliferative activity, Induce apoptosis, Maintain the dry level of tumor stem cells, Inducing normal cells to become cancerous by secreting aging phenotype

NBL-10, NBL-20, NBL-21, NBL-34

/

Sustaining proliferative signaling, Resisting cell death, Senescent cells, Unlocking phenotypic plasticity

IL-6, IL-8, p16, p23, p51, Lamin B1, SA-β-gal, Ki-67, PCNA, GRO, GRO-α, IL-7, TIMP-1, TIMP-2, VEGF-A, Angiogenin, IL-7, LaminA, α-SMA, SDF-1, TGF-β1, Akt, ERK, STAT3, JAK, AUF1, E-Cadherin, EpCAM, N-Cadherin, Vimentin, Twist1, ZEB1, CD34, ALDH, CD24, CD44, HIF-1α, Bmi-1, SOX2, NANOG, OCT4, KLF4, ZEB1

[136]

Luminal

Inhibit high proliferative activity, Promote tumor cell invasion and metastasis

/

Losartan

Sustaining proliferative signaling, Activating invasion & metabolism

α-SMA, E-Cadherin, STAT3, VEGFA, F4/80, CD3, AGTR1, AT₁R, TNF-α

[137]

Luminal

Inhibit high proliferative activity, Promote tumor cell invasion and metastasis, Maintain the dry level of tumor stem cells

SUM149, SUM190

Ruxolitinib, AZD1480, Solcitinib, Abrocitinib, Fedratinib, C188-9, SH-4–54

Sustaining proliferative signaling, Activating invasion & metabolism, Unlocking phenotypic plasticity

cAMP/PKA pathway, JAK2/STAT3 pathway, CREB, CD44, CD24, STAT3, IL-6, EpCAM, E-cadherin, Vimentin, PDE4A

[138]

Luminal

Inhibit high proliferative activity, Promote tumor cell invasion and metastasis, Maintain the dry level of tumor stem cells

MCF-7, T47D

siSTAT3, sip65, siCTRL

Sustaining proliferative signaling, Activating invasion & metabolism, Unlocking phenotypic plasticity

STAT3, STAT1, p65, IL-8, CXCL8, E-cadherin, CD44, CD24, PD-L1

[139]

Luminal

Inhibit high proliferative activity, Promote tumor cell invasion and metastasis, Maintain the dry level of tumor stem cells

Primary tumor cells

Stattic, LY-2157299

Sustaining proliferative signaling, Activating invasion & metabolism, Unlocking phenotypic plasticity

EGFR/STAT3 pathway, TGF-β/SMAD payhway, CD61, CD29, ALDH, CD24, Ki-67, Vimentin, Twist1, E-Cadherin, Snail, Slug, JAK2, SOCS3, Pias3

[140]

Luminal

Regulate the level of cell drug resistanc, Promote tumor cell invasion and metastasis, Promote tumor-related inflammation

MCF-7, BT-474, T47D, ZR751

shIL-6,

Activating invasion & metabolism, Tumor promoting inflammation

ER^lo/Notch^hi pathway, IL-6/STAT3 pathway, CD133, onco-miR-221, IL-6R, Vimentin, Fap, E-Cadherin, Fibronectin, Cavedin-1, ERα, Notch3, CD44

[141]

Luminal

Inhibit high proliferative activity, Induce apoptosis, Regulate the level of cell drug resistanc

MCF-7, T47D, TamR

Dasatinib, Stattic, siSTAT3

Sustaining proliferative signaling, Resisting cell death

EGFR, STAT3, p21(Cip1), ERα, Akt, GSK3β, P70S6K, ERK, SRC, CyclinD1, Cyclin D3, Rb, PRAP, Survivin, LaminB1

[142]

Luminal

Inhibit high proliferative activity, Regulate the level of cell drug resistanc

TamS, TamR, MCF-7

Akt IV, LY294002

Sustaining proliferative signaling,

FN, JNK, STAT3, Akt, E-cadherin

[143]

Luminal

Inhibit high proliferative activity, Promote tumor cell invasion and metastasis, Promote tumor-related inflammation

MCF-7, ZR75.30

BAY 11–7085

Sustaining proliferative signaling, Activating invasion & metabolism, Tumor promoting inflammation

NF-κB pathway,

STAT3 pathway, VEGFR2 pathways, G-CSF, IL-8, IL-6, VEGF, VCAM-1, E-selectin, ICAM-1, IκBα,

[144]

HER2

Induce apoptosis

SK-BR-3

miR-124

Resisting cell death

STAT3, PRAP

[148]

Luminal

Induce apoptosis, Promote epigenetic reprogramming

MCF-7

siCBS, siCSE,

Resisting cell death, Non-mutational epigenetic reprogramming

miR-155/NOS2/NO pathway, H2S synthesizing enzymes, cystathionine b-synthase, cystathionine c-lyase,

Akt, STAT3, ULPB2, MICA, IFN-β, TNF-α, CD80, CD86, 41BBL, HLA-DR, miR-4317

[149]

Luminal

Induce apoptosis, Promote tumor-related inflammation, Enhance immune evasion

SK-BR-3,

U0126, FcR

Resisting cell death, Tumor promoting inflammation, Avoiding immune destruction

MAPK pathway, IL-21R, STAT1, STAT3

[150]

Luminal

Induce apoptosis, Enhance immune evasion, Promote tumor cell invasion and metastasis, Promote tumor-related inflammation, Maintain the dry level of tumor stem cells

MCF-7, ZR751

/

Resisting cell death, Activating invasion & metabolism, Tumor promoting inflammation, Avoiding immune destruction, Unlocking phenotypic plasticity

TNF-α, TNFAIP3, STAT3, PRAP1, Bcl-2, Bax, HSP70, STAT1, SOCS3, Vimentin, SNAIL, CDH1, CLDN3, IL-6, IL-8, CCL5, TFG-β, CD44, CD24, CD11b

[151]

Luminal

Induce apoptosis, Enhance immune evasion, Controlled by genomic instability

T47D, MCF-7

Alpelisib, CH5132799, LY255283,

Resisting cell death, Avoiding immune destruction, Genome stability & mutation,

PI3K/5-LOX/LTB4 pathway, CD33, CD8, Akt, STAT3, PKC, cPLA2, BLT2, NOX1, NOX4, IκBα, NF-κB, CD3

[152]

HER2

Promote tumor cell invasion and metastasis, Maintain the dry level of tumor stem cells

SK-BR-3, BT20

/

Activating invasion & metabolism, Unlocking phenotypic plasticity

JAK2/STAT3 pathway, TrkA, SOX2, Myc, ALDH, CD24, CD44

[155]

HER2, Luminal

Regulate the level of cell drug resistanc, Maintain the dry level of tumor stem cells, Promote tumor-related angiogenesis

MDA-MB-468, BT-474

MEDI5117

Unlocking phenotypic plasticity, Inducing or accessing vascular

IL-6, gp130, STAT3, PECAM-1, KDR, CD31, Ki-67, CD44, CD24, IL-8, TGF-β, IFN-γ

[156]

Luminal

Maintain the dry level of tumor stem cells, Promote tumor cell invasion and metastasis, Promote tumor-related inflammation

4T1

Liposomal Nanoparticles Carrying anti-IL6R Antibody

Unlocking phenotypic plasticity, Activating invasion & metabolism, Tumor promoting inflammation,

IL-6/STAT3 pathway, CD44, SOX2, VEGFA, MMP9, CD206, IL-6R, CD31

[157]

HER2

Promote tumor cell invasion and metastasis

SK-BR-3, BT-474

shWASF3, siHER2, siHER3, Trastuzumab, AG490, S3I-201

Activating invasion & metabolism

JAK2/STAT3 pathway, HER2, WASF3, HER3, HSP90, ZEB1

[163]

Luminal

Promote tumor cell invasion and metastasis, Regulating cell metabolism

T47D

/

Activating invasion & metabolism, regulating cellular metabolism

Akt, ATP7A, CCS, Complex IV Sub II, SOD1, Fibronectin, α-SMA, E-Cadherin, Vimentin, Vehicle, TRIEN, ERK, GSK3β, SMAD3, STAT3, TGF-β, LOXL2, MMP2, MMP9

[164]

Luminal

Promote tumor cell invasion and metastasis, Promote epigenetic reprogramming

MCF-7, T47D

Ruxolitinib

Activating invasion & metabolism, Non-mutational epigenetic reprogramming

ER, STAT3, PR, Ki67, IL-6, FOXA1

[165]

HER2

Inhibit high proliferative activity, Regulate the level of cell drug resistance, Maintain the dry level of tumor stem cells, Promote tumor-related inflammation,

HCC1954

IRAKi, Cisplatin,

Sustaining proliferative signaling, Unlocking phenotypic plasticity, Tumor promoting inflammation

CD44, CD24, CXCL1, CCL20, IL-1α, CXCL8, IL-6, IL-1β, STAT3, p65, IκB, ERK, Akt, NF-κB, STAT3m

[168]

Luminal

Regulating cell senescence

NBL-10, NBL-34

siSTAT3

Senescent cells

E-Cadherin, EpCAM, N-Cadherin, Vimentin, Twist1, ZEB1, Snail, Slug, CD24, ALDH1/2, CD44, Bmi1, OCT4, KLF4, CD49, CK18, CK14, CD10, CD90, MUC-1, STAT3, AUF1, p16

[181]