The evolution of S-nitrosylation detection methodology and the role of protein S-nitrosylation in various cancers

Liang, Feng; Wang, Min; Li, Jiannan; Guo, Jie

doi:10.1186/s12935-024-03568-y

Cancer Cell International

Table 2 List of the active sites in SNO modification proteins and the function of SNO proteins in different cancers

From: The evolution of S-nitrosylation detection methodology and the role of protein S-nitrosylation in various cancers

Type of cancer	Author	Protein	Site	Cancer promotion/inhibition	References
Lung cancer	Azad et al	Bcl-2	Cys158, Cys229	Promotion	[115]
	Chanvorachote et al	Bcl-2	NA	Promotion	[116]
	Wright et al	Bcl-2	NA	Promotion	[117]
	Wang et al	FLIp	NA	Promotion	[118]
	Chanvorachote et al	Cav-1	NA	Promotion	[119]
	Zhang et al	Ezrin	Cys117	Promotion	[120]
	Zhang et al	Ezrin	NA	Promotion	[121]
	He et al	VEGFD	Cys277	Promotion	[122]
	Zhang et al	PRDX2	Cys51, Cys172	Inhibition	[123]
	Cao et al	STAT3	NA	Inhibition	[124]
	Soonnarong et al	p53	Cys182	Inhibition	[77]
	Okuda et al	HDAC6	NA	Inhibition	[125]
Colorectal cancer	Williams et al	p53, β-catenin, NF-κB	NA	Inhibition	[126]
	Kashfi	β-catenin, p65 of NF-κB, caspase-3	NA	Inhibition	[127]
	Leon-Bollotte et al	Fas	Cys304	Inhibition	[128]
	Romagny et al	cIAP1	Cys571, Cys574	Inhibition	[129]
	Pietrafesa et al	TRAP1	NA	Inhibition	[130]
	Li et al	GAPDH	NA	Inhibition	[131]
	Chattopadhyay et al	p65 of NF-κB	NA	Inhibition	[132]
	Rizza et al	FAK1	Cys459, Cys658	Promotion	[75]
	Okuda et al	DNMT3B	Cys651	Promotion	[79]
	Zhao et al	LTBP1	Cys833, Cys839	Promotion	[133]
	Sanhueza et al	HIF1α	Cys800, Cys520	Promotion	[134]
	Marino et al	ESR2	NA	Promotion	[135]
	Kumar et al	TOP2A	NA	Promotion	[136]
	Gupta et al	PTEN	Cys83	Promotion	[137]
Breast cancer	Zamorano et al	p120	NA	Promotion	[138]
	Koning et al	VCAM-1	NA	Promotion	[76]
	Cañas et al	APAF1, c-Jun, HSF1, CaN	NA	Promotion	[139]
	Rahman et al	c-Src	Cys498	Promotion	[140]
	Switzer et al	Ras	NA	Promotion	[141]
	Switzer et al	EGFR	NA	Promotion	[142]
	Talbott et al	FLIp	Cys254, Cys259	Promotion	[143]
	Feng et al	ERK	Cys183	Inhibition	[144]
	Bouaouiche et al	JAK2	NA	Inhibition	[145]
	Letson et al	TGFβ1	Cys355, Cys356, Cys389	Inhibition	[146]
Liver cancer	Tang et al	AGT	NA	Promotion	[147]
	Wei et al	AGT	NA	Promotion	[148]
	Rizza et al	TRAP1	Cys501	Promotion	[149]
Melanoma	Godoy et al	Caspase-3, PHD2	NA	Promotion	[150]
	Vavvas et al	Bcl-2	NA	Promotion	[151]
	Ferraz et al	Caspase-3	NA	Inhibition	[152]
Glioma	Jin et al	ERK1/2	Cys183	Inhibition	[153]
Glioma	Guequén et al	VE-cadherin, p120	NA	Promotion	[154]
Thyroid cancer	Du et al	GAPDH	NA	Inhibition	[155]
Pancreatic ductal adenocarcinoma	Tan et al	STAT3	Cys687	Inhibition	[156]
Head and neck cancer	Guan et al	MKP-1	Cys258	Promotion	[157]
Ovarian cancer	Chuu et al	STAT3, Akt, p65, EGFR	NA	Inhibition	[158]
	Tang et al	Apo2L/TRAIL receptor DR4	Cys336	Inhibition	[159]
	Saed et al	Caspase-3	NA	Promotion	[160]
	Gao et al	PFKM	Cys351	Promotion	[89]
Prostate carcinoma	Bonavida et al	p50 of NF-κB, Snail, YY1	NA	Inhibition	[161]
	Isaac et al	ITG α6	Cys86	Promotion	[162]
	Qin et al	AR	Cys601	Inhibition	[163]
	Firdaus et al	CSF1R	Cys224, Cys278, Cys830	Inhibition	[74]

NA: none

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ISSN: 1475-2867

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