Fig. 3
From: Cuproptosis: a promising new target for breast cancer therapy
Schematic of cuproptosis mechanism. Cuproptosis can be induced by the increase of intracellular free copper ion, which occurs through four modes of copper absorption, output and storage. SLC31A1 is a copper penetrase that is specific to Cu+. Inhibiting ATP7B can reduce copper exports. Excess Cu+ binds to the lipified DLAT and subsequently leads to oligomerization of DLAT. Cuproptosis is caused by Copper-mediated reduction of Fe-S stability