Table 1 Top Biological Processes and associated proteins modulated in VPA/SIM-treated tumor samples
Biological Process | Gene names | Protein names | UniProt Accession numbers | Fold- change VPA + SIM/CTR |
|---|---|---|---|---|
Cell architecture and cytoskeleton organization | CAN2 | Calpain-2 catalytic subunit | P17655 | -3.58 |
CAN1 | Calpain-1 catalytic subunit | P07384 | -7.74 | |
CPNS1 | Calpain small subunit | P04632 | -2.40 | |
ELN | Elastin | P15502 | -3.90 | |
MMP1 | Matrix metalloproteinase 1 | P03956 | -5.06 | |
MMP10 | Matrix metalloproteinase 10 | P09238 | -2.12 | |
LAMC1 | Laminin subunit gamma-1 | P11047 | -4.75 | |
POSTN | Periostin | Q15063 | -2.73 | |
RB11A | Ras-related protein Rab-11Â A | P62491 | -4.16 | |
MTAP2 | Microtubule-associated protein 2 | P11137 | -4.14 | |
PTPRM | Protein-tyrosine phosphatase mu | P28827 | -8.60 | |
ULK1 | Serine/threonine-protein kinase ULK1 | O75385 | -42.92 | |
Biological Metabolic Process | HCD2 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Q99714 | +2.01 |
ECHD2 | Enoyl-CoA hydratase | Q86YB7 | -2.92 | |
MDH1 | Malate dehydrogenase, cytoplasmic | P40925 | +2.33 | |
MDH2 | Malate dehydrogenase, mitochondrial | P40926 | +7.03 | |
SDHA | Succinate dehydrogenase, mitochondrial | P31040 | +6.93 | |
ACON | Aconitate hydratase, mitochondrial | Q99798 | +3.32 | |
CISY | Citrate synthase, mitochondrial | O75390 | -2.84 | |
ENOA | Alpha-enolase | P06733 | +2.88 | |
ALDOA | Fructose-bisphosphate aldolase A | P04075 | +2.89 | |
ASGL1 | Isoaspartyl peptidase/L-asparaginase | Q7L266 | -2.67 | |
G6PI | Glucose-6-phosphate isomerase | P06744 | +3.44 |