Fig. 3

Schematic representations of chemical modifications, delivery methods, and targeting approaches of ceRNA.(A) Schematic diagram illustrated the biogenesis of m6A-circRNAs and m6A-mRNA in OSCC cells. The m6A modification was installed by identical m6A methyltransferase complex (m6A writers). Red A indicated the m6A modification site. (B) ASOs, Exosome, PP@miR NPs, GO-PEI complex, T-miR-149, miR-181a-5p/AgNPs, mr-ber-PC, γδTDEs were applied for drug delivery system formation in OC therapy. (C) Targeting approaches of ceRNA. (a) A CRISPR-based transcription activation system to verify the formation and functionality of the artificial lncRNA. (b) In the presence of low sponge expression, target mRNAs are post transcriptionally repressed by the miRNA. (C) During infection, viral RNA specifically sequesters miR-122 to de-repress its normal host targets