Evaluation of functional magnetic resonance APT and DKI imaging for breast cancer

Table 6 ROC analysis of the diagnostic efficacy of the parameters for the prognostic factors of breast cancer

Factors	Multi parameters	AUC (95%)	P value	Youden index	Sensitivity (%)	Specificity(%)
ER	Kapp	0.695 (0.597–0.794)	0.001	0.361	51.3	84.8
	Dapp	0.690 (0.582–0.797)	0.002	0.367	70.0	66.7
	MTRasym	0.541 (0.426–0.656)	0.495	0.18	51.3	66.7
	ADC	0.677 (0.568–0.785)	0.003	0.26	77.5	48.5
PR	Kapp	0.651 (0.548–0.755)	0.009	0.262	77.6	48.6
	Dapp	0.638 (0.529–0.747)	0.018	0.279	68.4	59.5
	MTRasym	0.524 (0.412–0.636)	0.057	0.142	25.0	89.2
	ADC	0.665 (0.561–0.768)	0.005	0.287	39.5	89.2
HER-2	Kapp	0.650 (0.541–0.759)	0.027	0.369	91.3	45.6
	Dapp	0.650 (0.533–0.767)	0.027	0.263	69.6	56.7
	MTRasym	0.645 (0.526–0.764)	0.033	0.269	91.3	35.6
	ADC	0.699 (0.574–0.823)	0.003	0.352	65.2	70.0
Lymph node status	Kapp	0.596 (0.481–0.712)	0.099	0.271	73.0	54.1
	Dapp	0.546 (0.432–0.661)	0.427	0.163	54.1	62.2
	MTRasym	0.508 (0.394–0.622)	0.895	0.108	21.6	89.2
	ADC	0.629 (0.518–0.741)	0.027	0.23	50.0	73.0

Note Lymph node metastasis status was categorized as positive when lymph node metastases were present and negative when lymph node metastases were absent. No considerable difference in AUCs of other parameters and methods was noted
ADC, apparent diffusion coefficient; APT, amide proton transfer; AUC, area under the curve; ER, estrogen receptor; Dapp, apparent diffusivity; DKI, diffusion kurtosis imaging; HER-2, human epidermal growth factor receptor-2; Kapp, apparent kurtosis coefficient; MTRasym (3.5 ppm), asymmetric magnetization transfer ratio at 3.5 ppm

ISSN: 1475-2867