Fig. 5

WGCNA results. A. Network topology analysis of different soft threshold powers. B. Gene clustering dendrogram obtained by hierarchical clustering based on topological overlap (top) and module colors assigned by different gene clusters (bottom). Each color represents a different module, and the corresponding gene with the same color belongs to the same gene module. C. Heatmap of correlation between module and trait. Each row corresponds to a gene module. Each cell contains the corresponding correlation and P value; Red indicates a positive correlation and blue indicates a negative correlation. D. Scatter plot of GS versus MM in turquoise-colored modules. MM represents the correlation between the expression of eigengenes and genes. The genes in each module are highly correlated with the module to which they are assigned, indicating a high degree of connectivity within the module. GS represents the absolute value of the correlation between a gene and a phenotypic trait. Each point in the graph represents a gene. The abscissal value indicates the correlation between the gene and the module, and the ordinate value indicates the correlation between the gene and the phenotypic trait. There was a highly significant correlation between GS and MM. E. Bar chart of enrichment analysis results of BP, CC and MF in GO enrichment results of genes in turquoise-colored modules. F. Ring diagram of KEGG enrichment analysis of genes in turquoise-colored modules. GS: Gene significance, MM: Module Membership, GO: Gene Ontology, BP: Biological Process, CC: Cell Component, MF: Molecular Function, KEGG: Kyoto Encyclopedia of Genes and Genomes