Fig. 3

Correlation of LAT4 mRNA expression with GBM. (A) Venn diagram illustrating the intersection of differentially expressed genes in U-R vs. U-S, U-R IR vs. U-S IR, and U-R IR vs. U-R conditions, resulting in the identification of 21 genes shown in the right list. (B) GO-BP enrichment analysis of 21 overlapping genes. (C, D) Comparative box plot analysis of log2-transformed LAT4 mRNA expression levels across different tumor grades of II, III, and IV (C) with a significant difference observed (IV vs. II, P < 0.001; III vs. II, P < 0.001; Student T-test), or between primary and recurrent tumors with a significant difference observed (P < 0.001, Student pairwise t-tests; D). (E, F) Kaplan-Meier survival curves for patients stratified by high and low LAT4 mRNA expression levels. Both the log-rank p-value and the Wilcoxon p-value are shown, indicating a highly significant correlation between LAT4 expression and patient survival time. mRNA expression and survival data were derived from the CGGA database