Table 2 List of lnRNA-based biomarkers in early detection, monitoring, and prognosis of HCC

1

MALAT1

Regulation of miRNAs (miR-204, miR-143-3p, miR-30a-5p, miR-200a, miR-124-3p, miR-195, and miR-22) involving in EMT

[139]

2

CTBP

Detection of cirrhotic HCC

[140]

3

LINC00152, XLOC014172, RP11-160H22.5 + AFP

Differentiating HCC patients from those with cirrhosis, chronic hepatitis, and normal individuals

[141]

4

Linc00974

Elevated serum level in HCC patients

[142]

5

miRNAs miR-21, miR-199, and miR-122

Upregulation in HCC samples

[145, 146]

6

miR-145, miR-29a, miR-133a, miR-143, miR-505 miR-29c, and miR-192

Enhanced accuracy

[151]

7

miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a, and miR-801

HCC detection among healthy individuals or cirrhotic patients

[152]

8

miR-6885-5p, miR-663a, miR-320b, miR-4448, miR-4749-5p, miR-6724-5p, miR-6877-5p, andmiR-4651

Early stage detection of HCC

[132]

11

miR-4651

Poor outcome

[155]

12

miR-1, miR-122, miR-26a, miR-29a, and miR-223-3p, miR-155, miR-96, and miR-193-5p

Poor outcome

[156]

13

miR-424-5p and miR-101-3p, miR-128, miR-139-5p, miR-382-5p, and miR-410

Overall survival

[157]

14

miR-1246, miR-500

Predicting early relapse after surgery

[158, 159]

15

miR-122, miR-26a, miR-2

Prognostic indicators

[160]

16

miR-645, miR-200a, miR-122, miR-125b, miR-374b, miR-107, miR-15b, miR-320, and miR-30a

Overall survival

[163]