Skip to main content
Fig. 3 | Cancer Cell International

Fig. 3

From: GANT61 surmounts drug resistance of ADR by upregulating lysosome activities and reducing BCL2 expression in HL-60/ADR cells

Fig. 3

KEGG and GSEA results of RNA-seq data and the GSE107465 dataset. (A) Volcano plot of differential genes from RNA-seq of DMSO and GANT61 treatment HL-60/ADR cells. Red are up-regulated, Blue are down-regulated, and gray are no difference. (B) The DEGs were enriched to the top 10 enriched by KEGG from analysis of RNA-seq. (C) A GSEA plot showing enrichment of the gene set associated with the KEGG term “Apoptotic Cleavage of Cellular Proteins” in RNA-seq data. (D) The DEGs were enriched to the top 10 enriched by KEGG in from the GSE107465 dataset. (E) A GSEA plot showing enrichment of the gene set associated with the KEGG term “Apoptosis” in GSE107465 dataset. (F) The mRNA expression levels of apoptosis-related genes in HL-60/ADR cells treated with and without GANT61 were compared through an analysis of RNA-seq data. (G) A comparative analysis of apoptosis-related gene expression profiles between CR and RR patients in the GSE107465 dataset. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. ns, not significant

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us