Table 1 Various polyphenols in the cancer therapy

Breast cancer

Curcumin

Inhibited proliferation

In vitro

[91]

Head and Neck

Curcumin + Phototherapy

ATP synthase inhibition

In vitro, In vivo

[92]

Colorectal cancer

Curcumin

increased p53 molecule expression in tumor cells and consequently speeds up tumor cell apoptosis

Human

[68]

Breast cancer

Quercetin

Serve as a potential adjuvant for immune therapy

In vitro, In vivo

[93]

Hepatocellular carcinoma

Quercetin

Regulated degradation of RhoC level by targeting SMURF2

In vitro

[94]

Non-small cell lung cancer

Quercetin

Induced apoptosis

In vitro, in vivo

[95]

cancer

Resveratrol

Disrupted colorectal cancer metastasis by activating miR-125b-5p/TRAF6 signal pathway

In vitro

[96]

Colon cancer

Resveratrol

inhibited the Wnt pathway

Human

[70]

Colon cancer

Resveratrol

Inhibited cell proliferation

Human

[71]

Colon cancer

Resveratrol

Induced apoptosis

Human

[72]

Colrectal cancer

Silymarin

Reduced toxicities in mCRC patients undergoing first-line FOLFIRI plus bevacizumab

Human

[73]

Glioma

Silymarin

Enhanced the Nrf2/HO-1 pathway

In vitro

[97]

Prostate and cervical cancer

Garlic

Increased apoptosis and autophagy

In vitro

[98]

pancreatic tumor

Acetyl-l-cysteine- loaded niosomes

Increased apoptosis and autophagy

In vivo

[99]

Liver cancer

sorafenib/resveratrol PEGylated liposomes

Reduced cell proliferation

In vitro, In vivo

[100]

Osteosarcoma

Kaempferol

Reduced tumor growth inducing apoptosis and autophagy.

In vitro, In vivo

[101]

Colorectal cancer

Silymarin

Inhibited cell proliferation

In vitro, In vivo

[102]

Lung cancer

Kaempferol

An increase in the proportions of three types of immune cells

In vitro, In vivo

[103]

Gastric cancer

Coumarin

Modulated some lncRNAs that are related to anti-tumor response

In vitro

[104]

Prostate cancer

Benzylidene coumarin derivatives

Increased apoptosis and autophagy

In vitro

[105]