Fig. 3
From: Application prospects of ferroptosis in colorectal cancer
Targets lipid metabolism for CRC treatment by inducing ferroptosis. PUFAs are substrates for the synthesis of lipid signal transduction mediators and have been known to be sensitive to lipid peroxidation and play important roles in regulating ferroptosis. PUFAs can combine with PE and to form PUFA-PE under the action of the long chain member of ACSL4. Regulators of them will result in the misregulation of ferroptosis and affect the therapy