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Fig. 6 | Cancer Cell International

Fig. 6

From: Overexpression of metalloproteinase PAPPA accelerates cancer progression and correlates with immune cell infiltration in gastric cancer: insights from bioinformatics and in vitro investigations

Fig. 6

The possible biological pathways of PAPPA. A Volcano map demonstrates the distribution of differential genes associated with PAPPA in GC. B Heat map shows the top 20 differential genes. C PAPPA gene GO, KEGG analysis bubble diagram. D GSEA enrichment analysis of PAPPA in GC. The pathways that are enriched in extracellular matrix structures includes nuclear matrix pathway, extracellular matrix glycoprotein pathway, secretory factors and other pathways. E, F PAPPA protein interaction network diagram. Analysis of the network indicated that genes closely associated with PAPPA include IGF1, IGF2, IGFBP4, IGFBP5, IGFALS, and PRG2

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Cancer Cell International

ISSN: 1475-2867

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