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Table 1 Clinicopathological table

From: Comprehensive molecular analysis of 26 newly established human pancreatic ductal adenocarcinoma cell lines reveals two clusters with variating drug sensitivities

No.

Cell line

Sex

Age

Derived origin

Growth pattern

Doubling time

Cell morphology

Clinical stage

First treatment

Chemotherapy regimen (RESPONSE)

Surgery

1

SNU-2729B1

M

46

Tissue

Adherent

50.4

Polygonal

Metastatic

Chemotherapy

Gemcitabine/Erlotinib (Progressive disease)

Not applicable

2

SNU-2822

F

68

Ascites

Adherent

60.7

Fibroblast-like

Metastatic

Chemotherapy

Gemcitabine/Cisplatin (Stable disease)

Not applicable

3

SNU-2913

M

55

Ascites

Adherent

22.6

Fibroblast-like/Polygonal

Metastatic

Chemotherapy

FOLFIRINOX (Progressive disease)

Not applicable

4

SNU-2918

F

61

Ascites

Adherent

75

Oval

Resectable

Surgery

Not applicable

Pancreaticoduodenectomy

5

SNU-2982-1

F

71

Ascites

Adherent

66

Polygonal

Locally advanced

Chemotherapy

FOLFIRINOX (Stable disease)

Not applicable

6

SNU-3139

M

78

Tissue

Adherent

77.2

Polygonal

Locally advanced

Chemotherapy

5-fluorouracil (Stable disease)

Not applicable

7

SNU-3294

M

66

Tissue

Adherent

85.4

Polygonal

Borderline resectable

Surgery

Not applicable

Pancreaticoduodenectomy

8

SNU-3375

M

55

Tissue

Adherent

52.3

Round

Resectable

Surgery

Not applicable

Distal pancreatectomy

9

SNU-3573

M

49

Tissue

Adherent

67.6

Polygonal

Metastatic

Chemotherapy

FOLFIRINOX (Partial response)

Not applicable

10

SNU-3608

M

76

Tissue

Adherent

59.5

Polygonal

Resectable

Surgery

Not applicable

Distal pancreatectomy

11

SNU-3615

M

77

Tissue

Adherent

68.4

Oval/Round

Resectable

Surgery

Not applicable

Pancreaticoduodenectomy

12

SNU-3752

F

70

Tissue

Adherent

113

Polygonal/Round

Resectable

Surgery

Not applicable

Distal pancreatectomy

13

SNU-3923T*

M

69

Tissue

Adherent

80.4

Round

Resectable

Surgery

Not applicable

Pancreaticoduodenectomy

14

SNU-4208T*

M

45

Biopsy

Adherent

61.9

Round

Metastatic

Chemotherapy

FOLFIRINOX (Progressive disease)

Not applicable

15

SNU-4223

F

47

Tissue

Adherent

79.3

Polygonal

Borderline resectable

Surgery

Not applicable

Pancreaticoduodenectomy

16

SNU-4305T*

F

59

Biopsy

Adherent

45.1

Polygonal

Locally advanced

Chemotherapy

FOLFIRINOX (Stable disease)

Not applicable

17

SNU-4340T*

M

66

Biopsy

Adherent

85.1

Polygonal

Metastatic

Chemotherapy

FOLFIRINOX (Stable disease)

Not applicable

18

SNU-4354T*

F

64

Biopsy

Adherent

73.2

Polygonal

Locally advanced

Chemotherapy

FOLFIRINOX (Progressive disease)

Not applicable

19

SNU-4405

F

61

Tissue

Adherent

119.5

Polygonal

Resectable

Surgery

Not applicable

Distal pancreatectomy

20

SNU-4482

M

65

Tissue

Adherent

48.6

Polygonal

Resectable

Surgery

Not applicable

Total pancreatectomy

21

SNU-4492

F

80

Tissue

Adherent

37.9

Oval/Round

Resectable

Surgery

Not applicable

Distal pancreatectomy

22

SNU-4525

M

56

Tissue

Adherent

78.2

Oval

Resectable

Surgery

Not applicable

Distal pancreatectomy

23

SNU-4733

M

61

Tissue

Adherent

63.8

Polygonal

Resectable

Surgery

Not applicable

Distal pancreatectomy

24

SNU-4771

M

73

Tissue

Adherent

48.3

Polygonal

Resectable

Chemotherapy

FOLFIRINOX (Partial response)

Not applicable

25

SNU-4866

M

67

Tissue

Adherent

85.7

Polygonal

Resectable

Surgery

Not applicable

Pancreaticoduodenectomy

26

SNU-5177

F

57

Tissue

Adherent

92.3

Polygonal

Borderline resectable

Chemotherapy

FOLFIRINOX (Partial response)

Not applicable

  1. *Organoid-derived cell lines