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Fig. 3 | Cancer Cell International

Fig. 3

From: Mcl-1 downregulation enhances BCG treatment efficacy in bladder cancer by promoting macrophage polarization

Fig. 3

Mcl-1shRNA combined with BCG enhances the polarization of macrophages in the bladder cancer microenvironment towards the M1 type via the JNK signaling pathway. (A) TNF-α and IL-10 expression in the tumor microenvironment of MB49 bladder cancer cells. (B) Expression of CD86, INOS, CD206, and Arg-1 in MB49 cells across different groups. (C) Analysis of CD86, INOS, CD206, and Arg-1 protein expression. *P < 0.05, ***P < 0.001 compared with M0 + BCG-MB49 group; #P < 0.05, ##P < 0.01, ###P < 0.001 compared with M0 + BCG + Mcl-1shRNA-MB49 group

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Cancer Cell International

ISSN: 1475-2867

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