Fig. 1
From: Rack1 promotes breast cancer stemness properties and tumorigenesis through the E2F1-SOX2 axis
Elevated Rack1 is strongly associated with poor breast cancer prognosis and tumorigenesis (A) Analysis of the UALCAN database indicated that Rack1 protein expression levels were significantly higher in breast cancer tissues than in normal tissues. (B) Analysis of the Project Score database revealed that Rack1 is a core fitness gene that affects the health and cell viability of the majority of breast cancer cell lines. (C) Kaplan–Meier survival curve analysis showed that breast cancer patients with high Rack1 expression had a poorer prognosis. (D-E) The GSEA analysis showed that the Rack1 co-expressed genes were significantly enriched in the stemness, Wnt, hedgehog, Notch pathways based on the TCGA database