Table 5 microRNAs as potential biomarkers
From: Non-coding RNAs, a double-edged sword in breast cancer prognosis
miRNA | Change | Potential | Authors |
|---|---|---|---|
MiR-21 | TNBC tissues and cells, upregulated | Inhibition of miR-21 or overexpression of PTEN protein could be promising strategies for the treatment of patients with TNBC | Fang [200] |
MiR-34a | BC tissues and cell lines, significantly downregulated | MDR and prognosis indicator | Li [403] |
MiR-25-3p | TNBC in tissues and cell lines, upregulated | May identify new diagnostic and therapeutic targets in TNBC | Chen [404] |
BC–miR–10b | Elevated expression in BC tissues | Detection biomarker, a potential precursor to metastasis | Abdallah [405] |
MiR–125b | Increased expression in human TNBC tissues and cell lines | Potential prognosis biomarker and therapeutic target | Nie [406] |
MiR-145-5p | Lower expression in BC patients, leading to a poor survival rate | Predictive biomarker for BC stemness | Rajarajan [407] |
MiR–155 | BC cells, overexpression | Prognostic marker | Wang [408] |