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Fig. 4 | Cancer Cell International

Fig. 4

From: CircRNA hsa_circ_0004781 promoted cell proliferation by acting as a sponge for miR-9-5p and miR-338-3p and upregulating KLF5 and ADAM17 expression in pancreatic ductal adenocarcinoma

Fig. 4

Effects of the knockdown of hsa_circ_0004781 on the expression of miR-9-5p and miR-338-3p in PDAC cells. (A) Potential target miRNAs of hsa_circ_0004781 were predicted using ENCORI, circBank, and CircInteractome. miR-9-5p and miR-338-3p were selected on the basis of their downregulation in PDAC. Bioinformatics analysis predicted potential miR-9-5p and miR-338-3p binding sites on hsa_circ_0004781. (B) AsPC-1 and BxPC-3 cells were transfected with control siRNA (si-Ctr) or hsa_circ_0004781 siRNA (si-c4781) for 24 h. Total RNA was extracted, and the expression of miR-9-5p and miR-338-3p were determined through RT-qPCR. Values are presented as the mean ± SE from three independent experiments. #p < 0.001, ##p < 0.0001 vs. si-Ctr

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Cancer Cell International

ISSN: 1475-2867

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