Fig. 3

Identification of four subtypes of CAFs with distinct clinical outcome. a-b The distinct clusters (a) and types (b) of CAFs were identified in ER-positive breast cancer tissue visualized by UMAP; c The density of CAFs with specific marker were illustrated using UMAP. The color represents the density level of the cells with the marker.; d The markers used for annotation of CAFs. The size of the dot represents the proportion of cells expressing the gene in the corresponding cell cluster. The color of the dot represents the average expression level of the gene in the cell cluster; e-f The K-M curves showing the overall survival rate of high- and low- SOD3(+), COL1A2(+) MMP1(-), RPS17(+) and COL1A2(+) MMP1(+) CAFs