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Fig. 4 | Cancer Cell International

Fig. 4

From: Integrating spatial and single-cell transcriptomes reveals the role of COL1A2(+) MMP1(+/-) cancer-associated fibroblasts in ER-positive breast cancer

Fig. 4

The cell trajectory and heterogeneity of CAFs in tumor microenvironment. a The gene set enrichment analysis showing the biologic function of distinct CAFs. NES: normalized enrichment score; b The hallmark gene set enrichment analysis showing the enriched pathways in distinct CAFs; c The potential cell trajectory and lineages of CAFs in tumor microenvironment; d Two cell lineages of CAFs with the pseudo-time development; e The dynamic cell trajectory analysis confirming the changes of biological function and markers during the evolution of CAFs; f The cell developmental analysis showing the direction of COL1A2(+) MMP1(-) CAFs to COL1A2(+) MMP1(+) CAFs

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Cancer Cell International

ISSN: 1475-2867

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