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Fig. 6 | Cancer Cell International

Fig. 6

From: Integrating spatial and single-cell transcriptomes reveals the role of COL1A2(+) MMP1(+/-) cancer-associated fibroblasts in ER-positive breast cancer

Fig. 6

Exploration of the colocalization relation by spatial transcriptome. a UMAP confirmed the five distinct regions of spots; b Tumor region was identified though dimensionality reduction and experienced pathologists; c Heatmap showing the differential-expression genes between tumor-rich and tumor-scarce tissues; d Dot plot showing the enriched pathways in tumor-rich and tumor-scarce tissues; e The chart plot showing the importance score of cell types related to the distribution of COL1A2(+) MMP1(-) CAFs; f The chart plot showing the importance score of cell types related to the distribution of COL1A2(+) MMP1(-) CAFs; g-k The relative cell location of COL1A2(+) MMP1(-) CAFs (g), Treg (h), TAM (i), COL1A2(+) MMP1(+) CAFs (j), and pDC(k) in spatial position on the pathological section

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Cancer Cell International

ISSN: 1475-2867

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