Fig. 7

The somatic mutations were associated with the infiltration of COL1A2(+) MMP1(+/-) CAFs. a Forest plot demonstrating focal somatic single nucleotide variant (SNV) is significantly different between patients in the COL1A2(+) MMP1(-)-CAFs high and low infiltration level groups. OR > 1, higher SNV frequency for patients in the high infiltration level group. OR < 1, higher SNV frequency in low infiltration level group; b-c Landscape of gene co-mutations in patients with high (b) and low (c) abundance of COL1A2(+) MMP1(-) CAFs; d Forest plot demonstrating focal somatic single nucleotide variant (SNV) is significantly different between patients in the COL1A2(+) MMP1(+)-CAFs high and low infiltration level groups; e-f Landscape of gene co-mutations in patients with high (e) and low (f) abundance of COL1A2(+) MMP1(+) CAFs