Fig. 8

The radiomic model based in MRI was constructed for predicting the abundance of COL1A2(+) MMP1(+/-) CAFs in ER-positive breast cancer. a Schematic diagram of the radiomics analysis process; b An example of segmentation for gross tumor volume on DCE-T1 images; c Distribution of coefficients for variables in the LASSO regression; d Parameter tuning plot in least absolute shrinkage and selection operator (LASSO) regression; e-f Pearson’s correlations between z-score normalized abundance of COL1A2(+) MMP1(+/-) CAFs measured by the transcriptome and the fitted value by the linear regression radiomics model in the training cohort (e) and validation cohort (f)