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Fig. 2 | Cancer Cell International

Fig. 2

From: Repurposing pitavastatin and atorvastatin to overcome chemoresistance of metastatic colorectal cancer under high glucose conditions

Fig. 2

Pitavastatin and atorvastatin can overcome high glucose-induced drug resistance and synergistically promote 5-FU-mediated cytotoxicity. (A-C) Colony formation assay of SW480-LG and SW480-HG following treatment with 5-FU, pitavastatin, or atorvastatin for nine days. (D-E) The combination index (CI) of SW480-LG and SW480-HG cells treated with 5-FU in combination with pitavastatin or atorvastatin. CI defines synergism (CI < 1), an additive effect (CI = 1), and antagonism (CI > 1). (F-G) Colony formation assay of SW480-LG and SW480-HG following treatment with a combination of 5-FU and pitavastatin or atorvastatin. Data represent the mean ± SEM (N = 3). $: Denotes a comparison with the SW480-LG control; #: Indicates a comparison with the SW480-HG control; The number of symbols corresponds to the significance level: one symbol indicates p < 0.05; two symbols indicate p < 0.01; and three symbols indicates p < 0.001. LG: Low glucose; HG: High glucose

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Cancer Cell International

ISSN: 1475-2867

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