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Fig. 6 | Cancer Cell International

Fig. 6

From: Repurposing pitavastatin and atorvastatin to overcome chemoresistance of metastatic colorectal cancer under high glucose conditions

Fig. 6

Pitavastatin and atorvastatin induce apoptosis partly by stimulating autophagy and inducing ER stress. Western blotting data show the impact of various inhibitors on the expression of markers associated with autophagy, ER, and apoptosis. (A) SW480-LG and SW480-HG cells were co-treated with 3-MA and pitavastatin or atorvastatin. (B) Both SW480-vehicle and SW480-ATG5 KO cells were treated with pitavastatin and atorvastatin. (C) GSK2606414 was used in a cotreatment with pitavastatin or atorvastatin on SW480-LG and SW480-HG cells. LG: Low glucose; HG: High glucose

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Cancer Cell International

ISSN: 1475-2867

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