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Table 1 Summary of IC50 values for 5-FU, Pitavastatin, and Atorvastatin in SW480-LG and SW480-HG cells

From: Repurposing pitavastatin and atorvastatin to overcome chemoresistance of metastatic colorectal cancer under high glucose conditions

Drug

5-FU (µM)

Pitavastatin (µM)

Atorvastatin (µM)

Cell

SW480-LG

SW480-HG

SW480-LG

SW480-HG

SW480-LG

SW480-HG

Time

24 h

110.6 ± 2.0

240.7 ± 2.4*

6.3 ± 2.7

24.9 ± 1.3**

28.8 ± 1.4

93.4 ± 2.0*

48 h

24.0 ± 1.4

87.8 ± 1.9*

1.8 ± 0.9

3.5 ± 1.0

4.7 ± 1.5

9.1 ± 2.3

72 h

8.6 ± 2.0

18.1 ± 3.2***

0.4 ± 0.2

0.6 ± 0.2

1.6 ± 0.3

3.3 ± 0.9

  1. Data represent the mean ± SEM (N = 3). (*p < 0.05, **p < 0.01, ***p < 0.001 vs. SW480-LG cells)
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Cancer Cell International

ISSN: 1475-2867

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