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Table 2 Summary of IC50 values for 5-FU, Pitavastatin, and Atorvastatin in DLD-1 and DLD-1R cells

From: Repurposing pitavastatin and atorvastatin to overcome chemoresistance of metastatic colorectal cancer under high glucose conditions

Drug

5-FU (µM)

Pitavastatin (µM)

Atorvastatin (µM)

Cell

DLD-1

DLD-1R

DLD-1

DLD-1R

DLD-1

DLD-1R

Time

24 h

408.7 ± 2.6

1010 ± 3.0*

110.5 ± 2.0

42.1 ± 1.6

64.2 ± 1.8

59.7 ± 1.8

48 h

4.1 ± 0.8

154 ± 2.2**

6.3 ± 3.2

5.8 ± 3.7

8.1 ± 2.4

7.3 ± 1.5

72 h

1.8 ± 0.8

176 ± 2.3***

3.7 ± 0.7

3.1 ± 0.5

5.4 ± 0.5

5.5 ± 0.7

  1. Data represent the mean ± SEM (N = 3). (*p < 0.05, **p < 0.05, ***p < 0.001 vs. DLD-1R cells)
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Cancer Cell International

ISSN: 1475-2867

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