Intratumoral microbiota for hepatocellular carcinoma: from preclinical mechanisms to clinical cancer treatment

Chen, Muhua; Bie, Lei

doi:10.1186/s12935-025-03745-7

Cancer Cell International

Table 1 Types of intratumoral microbiota in HCC

From: Intratumoral microbiota for hepatocellular carcinoma: from preclinical mechanisms to clinical cancer treatment

Dominant intratumoral microbiota	Taxonomies	Class of HCC	Microbes test	References
phyla Actinobacteria Firmicutes Proteobacteria	Phylum	HBV(+) Drinker	RNA-sequencing data from The Cancer Genome Atlas (TCGA)	[36]
Pantoea agglomerans E. coli 55,989	Genus	HBV(+) Drinker	RNA-sequencing data from The Cancer Genome Atlas (TCGA)	[36]
Proteobacteria Actinobacteria	Phylum	HCC	16S rDNA sequencing	[37]
Holophaga Ornithinimicrobium Sediminibacterium Roseivirga Pantoea Candidatus ontendobacter Caldimonas Shuttleworthia Desulfosarcina Melissococcus Crenobacter Acidithrix Methylohalobius Rheinheimera	Genus	TCGA-LIHC microbiome dataset	Unknown	[39]
Cutibacterium	Genus	HBV-related HCC	16S rRNA sequencing	[40]
Enterobacteriaceae Fusobacterium Neisseria	Genus	HCC	16S rRNA sequencing	[41]
Firmicutes Proteobacteria Bacteroidetes	Phylum	HCC Mouse model	2bRAD sequencing	[42]
Lactobacillus Mycoplasma Escherichia	Genus
Mycoplasma_sp_U2014 Escherichia coli Allobacillus sp SKP4-8	Species
Bacteroidetes Firmicutes Proteobacteria	Phylum	HCC	16S rRNA sequencing	[43]
Bacteroides Romboutsia uncultured bacterium of Lachnospiraceae	Genus	HCC
Ruminococcus gnavus	Genus	HBV + and/or HCV +
Artverviricota	Phylum	HBV +	Metagenomics next-generation sequencing	[11]
Revtraviticetes	Class	HBV +	Metagenomics next-generation sequencing	[11]
Oscillospira Mucispirillum Helicobacter Roseburia Ruminococcus Anaerotruncus	Genus	HCC	16S rDNA sequencing	[13]
Streptococcaceae Lactococcus	Genus	HCC cirrhosis	16S rRNA sequencing	[22]
Staphylococcus Caulobacter	Genus	HBV-negative HCCs	16S rRNA sequencing	[22]
Rhodobacter Megasphaera	Genus	HCC	16S rRNA sequencing	[116]

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ISSN: 1475-2867

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