Fig. 3

High Infiltration of M_Macrophage-SPP1-C1Q in BC Correlates with Poor Prognosis. A Heatmap displaying the relative expression levels of ligand-receptor pairs among all immune cells in treatment responders compared to non-responders. B Key ligand-receptor pairs between different treatment response groups. Dot size represents the probability of communication for specific ligand-receptor pairs between sender and receiver clusters. C Heatmap showing Spearman correlation coefficients between proportions of different cell subsets. D Forest plot illustrating univariate Cox regression analysis of OS for each TAM subset in the GSE58812 cohort. E Infiltration abundance of M_Macrophage-SPP1-C1Q in chemotherapy-sensitive and chemotherapy-resistant patients. F Infiltration abundance of M_Macrophage-SPP1-C1Q in patients with and without metastasis. G, H Kaplan–Meier survival curves for MFS (left) and OS (right) among patients with high and low M_Macrophage-SPP1-C1Q infiltration in the GSE58812 and METABRIC cohorts