Fig. 4

Genetic mutations and DNA methylation of CLEC12A in pan-cancer. (A) Mutation frequency of CLEC12A in pan-cancer. (B) Mutational distributions of CLEC12A in pan-cancer. (C) The SNV profile of CLEC12A in pan-cancer. (D) Bubble plot shows the spearman correlation between CLEC12A expression and methylation in pan-cancer. Positive and negative associations are depicted in red and blue, respectively. (E) Bubble plot illustrating differential CLEC12A methylation patterns across cancer types; red bubbles indicate hypermethylation, while blue bubbles represent hypomethylation (the higher the significance, the larger the bubble)