Fig. 2
Comparison of clinical characteristics and immune infiltration between two consistently clustered MQRG subtypes in LUAD specimens. (A) Investigation of prognostic MQRGs by clustering analysis utilizing consensus matrix heatmaps. Two clusters discovered with a value of k = 2 were shown along with their corresponding correlation regions. (B) Based on the PCA analysis of the prognostic MQRGs, two groups of patients were found in the different subtypes of MQRG. Blue and yellow dots denote MQRGcluster A and MQRGcluster B. (C) Kaplan-Meier curves for OS of the two MQRG subtypes (chi-square test, P < 0.001). (D) Heat map illustrating the variations in clinical characteristics and expression levels of MQRGs between MQRGcluster A and B. (E) A GSVA which compares the biological pathways of two distinct subtypes, in which red denotes pathways that are activated, and blue denotes those that are suppressed. (F) GSVA of molecular function between two different subtypes, where blue and red, respectively, stand for blocked and activated pathways. (G) The prevalence of 23 distinct kinds of infiltrating immune cells in the two MQRG subtypes. MQRGs, mitochondrial quality-related genes; LUAD, lung adenocarcinoma; PCA, principal components analysis; OS, overall survival. GSVA, gene set variation analysis; *p < 0.05, **p < 0.01, ***p < 0.001; TME, tumor microenvironment