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Fig. 5 | Cancer Cell International

Fig. 5

From: A novel mitochondrial quality regulation gene signature for anticipating prognosis, TME, and therapeutic response in LUAD by multi-omics analysis and experimental verification

Fig. 5

Tumor mutation landscape outcomes were analyzed across different MQRG score groups, and nomograms were created for LUAD patients. (A) The TMB expression in different MQRG scores. (B) The analysis used the Spearman correlation between TMB and MQRG scores. (C) Links between the CSC index and MQRG scores. (D) Results of survival analyses for high and low TMB patients in the TCGA-LUAD cohort. (E) Variations in OS among high and low TMB from TCGA. (F) Somatic mutation features result in high MQRG scores. (G) Somatic mutation features result in low MQRG scores. Every column denoted a distinct patient. The top barplot showed the expression of TMB. The numerical value on the right corresponds to the mutations frequency in each gene. The right barplot illustrates the percentage of each kind of variation. (H) Graph of nomogram generated using clinicopathological factors and MQRG score. (I) calibration plot implemented to verify the nomogram. LUAD, lung adenocarcinoma. TMB, tumor mutation burden; CSC, cancer stem cell

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Cancer Cell International

ISSN: 1475-2867

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