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Fig. 6 | Cancer Cell International

Fig. 6

From: Single-cell transcriptome sequencing reveals the mechanism of Realgar improvement on erythropoiesis in mice with myelodysplastic syndrome

Fig. 6

Enrichment analysis of differentially expressed genes in erythroblasts from in vivo experiments. (A) Volcano plot showing DEGs, with red dots indicating significantly upregulated genes (P ≤ 0.05, |Log2 FC|≥ 0.25) and blue dots representing significantly downregulated genes (P ≤ 0.05, |Log2 FC|≥ 0.25). The top 10 DEGs are labeled. (B) Venn diagram illustrating the overlap of upregulated DEGs in erythroblasts between the WT vs. NHD13 and Realgar vs. NHD13 comparisons, revealing 17 overlapping genes. (C) GO enrichment analysis of upregulated DEGs in the Realgar vs. NHD13 comparison. (D) Enrichment plot from Gene Set Enrichment Analysis (GSEA) comparing differentially regulated genes in the Realgar group versus the NHD13 group. GSEA was conducted using GSEA software (v4.1.0) and MSigDB, with one-sided statistical tests and adjustments for multiple comparisons. Black bars represent individual genes, and enrichment is indicated in green. Normalized enrichment score (NES) is displayed. (E) KEGG enrichment analysis of upregulated DEGs in the Realgar vs. NHD13 comparison

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Cancer Cell International

ISSN: 1475-2867

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