Fig. 1
From: The emerging functions and clinical implications of circRNAs in acute myeloid leukaemia
Biogenesis, degradation and regulatory functions of circRNAs. A Biogenesis of exonic circRNAs (ecircRNAs), exon‒intron circRNAs (EIciRNAs), intronic circRNAs (ciRNAs), intergenic circRNAs, read‒through circRNAs (rt-circRNAs), fusion circRNAs (f-circRNAs), tRNA intronic circular RNAs (tricRNAs), and mitochondria‒encoded circRNAs (mecciRNAs) and the potential mechanisms of circRNA degradation. B Potential regulatory mechanisms of circRNAs. (a) CircRNAs can serve as microRNA sponges to block microRNA-mediated target gene silencing. (b) CircRNAs can interact with DNA to form circR loops. (c) CircRNAs can regulate the functions of RBPs (I), recruit transcription activators (II), act as protein scaffolds (III), and interact with specific proteins (IV). (d) CircRNAs can be translated into proteins or peptides