Table 5 Overview of dysregulated circRNAs in AML

CircMYBL2 (Hsa_circ_0006332)

MYBL2

↑ in FLT3-ITD⁺ AML

Bind to PTBP1

FLT3, STAT5, c-MYC, MCL1, p27/Kip1

Proliferation (+); Apoptosis (−); Cell cycle progress (+); Differentiation (−); Drug resistance (+)

[46]

Hsa_circ_0004136 (Circ_KCNQ5)

KCNQ5

↑ in AML; ↑ in the exosomes derived from AML serum and cell lines

Sponge miR-142; Sponge miR-622 and derepress RAB10; Sponge miR-570-3p and derepress TSPAN3

PCNA

Proliferation (+); Apoptosis (−); Cell cycle progress (+); Migration and invasion (+)

[72, 140, 141]

Hsa_circ_0009910

MFN2

↑ in AML; ↑ in the exosomes derived from AML cell lines

Sponge miR-20a-5p; Sponge miR-5195-3p and derepress GRB10

Bax, Bcl-2

Proliferation (+); Apoptosis (−); Cell cycle progress (+)

[73, 148]

Circ-ANXA2 (Hsa_circ_0035559)

ANXA2

↑ in AML

Target miR-23a-5p and miR-503-3p

NR

Proliferation (+); Apoptosis (−); Drug resistance (+)

[74]

CircTASP1 (Hsa_circ_406083; Hsa_circ_0007340)

TASP1

↑ in AML

Sponge miR-515-5p and upregulate HMGA2

Bax, Cleaved caspase-3, Bcl-2

Proliferation (+); Apoptosis (−); Cell cycle progress (+)

[75]

CircRNF220 (Hsa_circ_0012152)

RNF220

↑ in AML; ↑ in AML serum

Through miR-30a/MYSM1, miR-30a/IER2; miR-625-5p/SOX12; miR-330-5p/SOX4 axis

CyclinD1, Cleaved caspase-3; NF-κB, mTOR, FoxO signaling

Proliferation (+); Apoptosis (−); Cell cycle progress (+); Differentiation (−); Migration and invasion (+)

[76, 134, 135]

CircZBTB46 (Hsa_circ_103104)

ZBTB46

↑ in AML

Sponge miR-671-5p and derepress SCD

PI3 K-AKT, MAPK, mTOR signaling

Proliferation (+); Cell cycle progress (+); Ferroptosis (−)

[77]

CircBCL11B

BCL11B

↑ in AML

NR

NR

Proliferation (+); Apoptosis (−)

[84]

Hsa_circ_0079480

ISPD

↑ in AML

Sponge miR-654-3p and derepress HDGF

NR

Proliferation (+); Apoptosis (−)

[119]

F-circPR

PML-RARα

de novo in AML

NR

AKT signaling

Proliferation (+); Apoptosis (−); Drug resistance (+)

[120]

F-circM9

MLL-AF9

de novo in AML

NR

MAPK, AKT signaling

Proliferation (+); Apoptosis (−); Drug resistance (+)

[121]

Circ-PTK2 (Hsa_circ_104700; Hsa_circ_0005273)

PTK2

↑ in AML

Sponge miR-330-5p and upregulate FOXM1

CyclinD1, Bcl-2, Bax

Proliferation (+); Apoptosis (−)

[122]

Circ_POLA2

POLA2

↑ in AML

Target mature miR-34a and upregulate PD-L1

CDK4, CDK6

Proliferation (+); Cell cycle progress (+)

[123]

Circ_DLEU2 (Hsa_circ_0000488)

DLEU2

↑ in AML

Sponge miR-582-5p and upregulate COX2; Sponge miR-496 and upregulate PRKACB

Ki67, Bcl-2, Bax

Proliferation (+); Apoptosis (−); Cell cycle progress (+)

[124]

Circ_0094100

NR

↑ in AML

Sponge miR-217 and derepress ATP1B1

PCNA, CyclinD1, Bcl-2

Proliferation (+); Apoptosis (−); Cell cycle progress (+)

[125]

CircNFIX

NFIX

↑ in AML

Sponge miR-876-3p and derepress TRIM31

CyclinD1, Bcl-2, Cleaved caspase-3

Proliferation (+); Apoptosis (−); Cell cycle progress (+)

[126]

Hsa_circ_0000370

FLI-1

↑ inAML; ↑ in FLT3-ITD⁺ AML

Sponge miR-1299 and upregulate S100 A7 A

NR

Proliferation (+); Apoptosis (−); Cell cycle progress (+)

[127]

Circ_0104700

HOMER2

↑ in AML

Sponge miR-665 and derepress MCM2

JAK/STAT

signaling

Proliferation (+); Apoptosis (−); Cell cycle progress (+)

[128]

Hsa_circ_0044907

RPS6 KB1

↑ in AML

Sponge miR-186-5p and derepress KIT

PCNA, CyclinD1, Cleaved caspase-3

Proliferation (+); Apoptosis (−); Cell cycle progress (+)

[129]

Hsa_circ_0002483

PTK2

↑ in AML

Sponge miR-758-3p and derepress MYC

Cleaved caspase-3, caspase-3, Bax,

Bcl-2

Proliferation (+); Apoptosis (−); Cell cycle progress (+)

[130]

Hsa_circ_

0005774

CDK1

↑ in AML

Sponge miR-192-5p and upregulate ULK1

PCNA, CyclinD1, Bcl-2

Proliferation (+); Apoptosis (−); Cell cycle progress (+)

[131]

CircSPI1

SPI1

↑ in AML

Sponge miR-1307-3p, miR-382-5p, miR-767-5p; Interact with eIF4 AIII

PU.1, p-ERK1/2, Bcl-2, CDK6; Ras, PI3 K/AKT, p53, JAK-STAT, FoxO signaling

Proliferation (+); Apoptosis (−); Differentiation (−)

[132]

CircSH3BGRL3

SH3BGRL3

↑ in AML

Sponge miR-375-3p and derepress YAP1

NR

Proliferation (+); Cell cycle progress (+); Differentiation (−); Drug resistance (+)

[133]

CircRNF13 (Hsa_circ_0001346)

RNF13

↑ in AML

Sponge miR-1224-5p

c-MYC, caspase-3/7, Tenascin-C

Proliferation (+); Apoptosis (−); Cell cycle progress (+); Migration and invasion (+)

[136]

CircRAD18

RAD18

↑ in AML

Sponge miR-206 and derepress PRKACB

Bax, Bcl-2, Cleaved caspase-3

Proliferation (+); Apoptosis (−); Cell cycle progress (+); Migration and invasion (+)

[137]

CircPLXNB2 (Hsa_circ_0001257)

PLXNB2

↑ in AML

Sponge miR-654-3p and derepress CCND1

PLXNB2, CyclinD1, Bax, PCNA, Bcl-2

Proliferation (+); Apoptosis (−); Cell cycle progress (+); Migration and invasion (+)

[138, 139]

Hsa_circ_0013880

TXNIP

↑ in AML

Target USP32/Rap1b axis

CyclinD1, Cleaved caspase-3/9, Cleaved-PARP, CDK4, p21

Proliferation (+); Apoptosis (−); Cell cycle progress (+); Migration and invasion (+)

[142]

Circ-SFMBT2 (Hsa_circ_0017639)

SFMBT2

↑ in AML; ↑ in AML serum

Sponge miR-582-3p and upregulate ZBTB20

CyclinD1, MMP9, Bax

Proliferation (+); Apoptosis (−); Migration and invasion (+)

[143]

Hsa_circ_0003602 (Circ-SMARCC1)

SMARCC1

↑ in AML

Sponge miR-502-5p and upregulate IGF1R

NR

Proliferation (+); Apoptosis (−); Migration and invasion (+)

[144]

Circ_0058058

NR

↑ in AML

Sponge miR-4319 and upregulate EIF5 A2

CyclinD1, Bcl-2, Cleaved caspase-3

Proliferation (+); Apoptosis (−); Migration and invasion (+)

[145]

CircPVT1

PVT1

↑ in AML

Stabilize c-Myc protein

CXCR4

Proliferation (+); Apoptosis (−); Migration and invasion (+)

[146]

CircNPM1 (Circ_0075001)

NPM1

↑ in AML; ↑ in AML serum

Sponge miR-345-5p and derepress FZD5

NR

Proliferation (+); Apoptosis (−); Cell cycle progress (+); Migration and invasion (+); Drug resistance (+)

[147]

Hsa_circ_0035381

PIGB

↑ in AML

Sponge miR-582-3p

and derepress YWHAZ

LC3-II/I, Beclin1

Proliferation (+); Apoptosis (−); Cell cycle progress (+); Autophagy (+); Oxidative stress (−)

[149]

Circ_001264

ST6GALNAC3

↑ in AML; ↑ in AML cell-derived exosomes

Sponge miR-502-5p and derepress RAF1

p38-STAT3

Proliferation (+); Apoptosis (−); M2 polarization of macrophages (+)

[150]

Hsa_circ_0121582

GSK3β

↓ in AML

Sponge miR-224 and derepress GSK3β; Interact with TET1

Wnt/β-catenin signaling

Proliferation (−); Cell cycle progress (−)

[151]

Hsa_circ_0001947

AFF2

↓ in AML

Sponge miR-329-5p and upregulate CREBRF

NR

Proliferation (−); Apoptosis (+)

[152]

CircCRKL

CRKL

↓ in AML

Through miR-196a-5p/miR-196b-5p/p27 axis

NR

Proliferation (−); Cell cycle progress (−)

[153]

Circ_0040823

BANP

↓ in AML; ↓ in AML serum

Sponge miR-516b and derepress PTEN

CyclinD1, CyclinE1, Bcl-2, Bax, Cleaved caspase-3

Proliferation (−); Apoptosis (+); Cell cycle progress (−)

[154]

Circ_0004277

WDR37

↓ in AML

Sponge miR-134-5p and derepress SSBP2

NR

Proliferation (−); Migration and invasion (−)

[155]

Hsa_circ_0001187

DOPEY2

↓ in AML

Sponge miR-499a-5p and upregulate RNF113 A

METTL3, MDM2, p53, p21

Proliferation (−); Apoptosis (+); Differentiation (+)

[156]

CircKDM4 C

KDM4 C

↓ in AML

Sponge hsa-let-7b-5p and upregulate p53

ACSL4, PTGS2, GPX4, FTH1

Proliferation (−); Migration and invasion (−); Ferroptosis (+)

[157]

Circ-HIPK2

HIPK2

↓ in ATRA-treated NB4 cells

Sponge miR-124-3p

NR

ATRA-induced differentiation (+)

[79]

Hsa_circ_0003420

NR

↓ in non-M3 AML stem cells

Target IGF2BP1

Cleaved caspase-3,

Bax, Bcl-2, HOXB4, MYB, ALDH1 A1

Stemness (−)

[165]

CircPAN3

PAN3

↑ in ADM-resistant AML cells

Through the regulation of autophagy; miR-153-5p/miR-183-5p-XIAP axis

LC3-II/I, Beclin1, p62, Cleaved caspase-3/9; AMPK/mTOR signaling

Autophagy (+); Drug resistance (+)

[80, 166]

CircEHBP1

EHBP1

↑ in AML; ↑ in ADR-resistant AML cells

Suppress miR-129 maturation

NR

Drug resistance (+)

[167]