Fig. 3
From: Germline variants in patients from the Iranian hereditary colorectal cancer registry
Circular visualization of clinical characteristics of patients with variants in Lynch-related and FAMP/MAP genes. (A) 27 patients had P (pathogenic)/LP (Likely Pathogenic) and VUS (variants of uncertain significance) variants in Lynch-related genes. Rectangles with green gradients represent the clinical characteristics of patients with the MSH2 variants. Rectangles with blue gradients represent the clinical characteristics of patients with the MLH1 variants. Rectangles with orange gradients represent the clinical characteristics of patients with the PMS2 variants. Rectangles with purple gradients represent the clinical characteristics of patients with the MSH6 variants. The white rectangles show unknown characteristics. The white rectangle in the center of the circle shows the characteristics of the rsID number for dbSNP, Mis-s: missense, Fram-sh: frameshift, Del: deletion, Ins: Insertion, Splice-D: splice donor, and Non-s: nonsense. The red words correspond to the novel variants. (B) 25 patients had P/LP/VUS variants in FAP/MAP genes in polyposis patients. Rectangles with purple gradients represent the clinical characteristics of patients with the APC variants, and rectangles with gold gradients represent the clinical characteristics of patients with the MUTYH variants