Table 3 Clinic-pathological characteristics of polyposis patients
From: Germline variants in patients from the Iranian hereditary colorectal cancer registry
| Â | Â | Patients with P/LP mutations in APC | Patients with P/LP mutations in MUTYH | Patients with P mutations in non-FAP/MAP genes | Patients with colorectal polyposis |
|---|---|---|---|---|---|
Number of patients | Â | 19 | 6 | 3 | 38 |
Mean age (year) | Â | 43.9 | 42.3 | 46 | 46.26 |
Age at diagnosis (year) | ≥ 50 | 26.3% (n = 5) | 16.7% (n = 1) | n = 1 | 36.8% (n = 14) |
|  | ≤ 50 | 73.6% (n = 14) | 83.3% (n = 5) | n = 2 | 63.15% (n = 24) |
Sex | Female | 42.1% (n = 8) | 66.7% (n = 4) | n = 2 | 39.47% (n = 15) |
|  | Male | 57.89% (n = 11) | 33.3% (n = 2) | n = 1 | 60.5% (n = 23) |
Number of colon polyps | 10–49 | 15.78% (n = 3) | 33.3% (n = 2) | n = 2 | 13.15% (n = 5) |
|  | 50–100 | 5.2% (n = 1) | 33.3% (n = 2) |  | 15.78% (n = 6) |
|  | ≥ 100 | 78.9% (n = 15) | 33.3 (n = 2) | n = 1 | 52.63% (n = 20) |
CRC | Yes | (n = 7) | (n = 2) | n = 1 | 26.31% (n = 10) |
Location of colorectal tumor | Distal | (n = 3) | (n = 1) |  | 10.52% (n = 4) |
|  | Proximal | (n = 2) | (n = 1) | n = 1 | 13.15% (n = 5) |
|  | Rectum | (n = 2) | 0 |  | 10.52% (n = 4) |
Mean age at CRC diagnosis (year) | Â | 45.8 | 37.5 | 57 | 47.3 |
CRC in first-degree relatives |  | (n = 7) | (n = 3) | (n = 2) | (n = 16) |
FAP extra colonic manifestations | Â | Thyroid nodule (2) | 0 | Thyroid nodule (1) | Thyroid nodule (6) |
| Â | Â | Desmoid tumor (3) | Â | Â | Desmoid tumor (3) |
| Â | Â | Duodenal polyp (4) | Â | Â | Duodenal polyp (4) |
CRC staging * | TIS | 0 | 0 | 0 | (n = 1) |
|  | I | 0 | (n = 1) | 0 | (n = 1) |
|  | II | (n = 1) | 0 | 0 | (n = 2) |
|  | III | (n = 1) | (n = 1) | 0 | (n = 2) |
|  | IV | (n = 2) | 0 | 0 | (n = 4) |