Fig. 2
From: Carbonyl reductase 4 suppresses colorectal cancer progression through the DNMT3B/CBR4/FASN/mTOR axis
Over-expression of CBR4 suppresses cell proliferation, migration and invasion. (A) mRNA levels of CBR4 were analyzed in both over-expressing and control colorectal cancer (CRC) cells. (B) Western blot analysis was conducted to assess the changes in protein levels of CBR4 in over-expressing versus control CRC cells. (C-D) The over-expression of CBR4 resulted in a significant inhibition of proliferation in RKO (C) and SW480 (D) cells, as determined by the CCK8 assay. (E-F) The up-regulation of CBR4 led to a reduction in the number of colonies formed. (G-H) CBR4 was found to suppress migration and invasion in RKO and SW480 cells, with a magnification of ×100. (***P < 0.001)