Fig. 5
From: Carbonyl reductase 4 suppresses colorectal cancer progression through the DNMT3B/CBR4/FASN/mTOR axis
CBR4 suppresses mTOR pathway mediated by FASN. (A) Volcano plot illustrating genes with relatively high and low expression levels in CBR4 knockdown colorectal cancer (CRC) cells. (B-C) KEGG and Gene Ontology (GO) analyses of differentially expressed genes between CBR4 knockdown and control CRC cells. (D-F) Western blot analysis of mTOR and phosphorylated mTOR (p-mTOR) in groups with CBR4 overexpression, CBR4 downregulation, and CBR4 downregulation combined with orlistat treatment