Fig. 9
From: Identification and validation of platinum resistance signature in gastric cancer
Identification of platinum resistance genes in vitro and in vivo. (A) IC50 detection of N87 and MKN45 cells, and related drug-resistant strains. (B) The mRNA expression levels of 21 platinum resistance genes by real time PCR in parental and resistant cells. (C) Representative images of two GC organoids treated with CDDP in Day 0 and Day 2. (D) 21 platinum resistance gene levels in PDO-1T and 2T treated with CDDP for 2 days, compared with non-treated PDOs. (E) Photographs of tumors derived from nude mice injected with PDX-4918 treated with or without CDDP, and tumor growth kinetics in the two groups. (F) The expression levels of platinum resistance genes in PDX-4918 model. (G) Heatmap of 21 platinum resistance gene levels in drug resistant cell lines, PDOs and PDX models. The data are the mean ± SD of three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001