Table 1 Role of miR-126 in cancer and exercise
Context | Type | miR-126 Expression | Molecular Mechanism | Reference |
|---|---|---|---|---|
Exercise | Chronic Aerobic Exercise | Increased | Dose-response, induces VEGF, EPC mobilization | |
Acute Aerobic Exercise | Increased | Hypoxia-induced HIF-1α, Ets-1 regulation | ||
HIIT | Increased | Influenced by training level and exercise duration | ||
cancer | Glioblastoma | Decreased | Associated with improved survival with higher levels | [87] |
Hepatocellular Carcinoma | Decreased | Tumor suppression by oncogene inhibition | [88] | |
Prostate Cancer | Decreased | Targets ADAM9 to inhibit proliferation and metastasis | [146] | |
Colorectal Cancer | Decreased | Regulates CXCR4, decreases metastasis and stage severity | [147] | |
Non-Small Cell Lung Cancer | Decreased | Inhibits PI3K-Akt pathway, enhances chemotherapy sensitivity | [148] | |
Ovarian Cancer | Decreased | Inhibits ERK/MAPK signaling and EMT | [93] |